• English
    X

    Google Translate Disclaimer

    The Maryland Department of Information Technology (“DoIT”) offers translations of the content through Google Translate. Because Google Translate is an external website, DoIT does not control the quality or accuracy of translated content. All DoIT content is filtered through Google Translate which may result in unexpected and unpredictable degradation of portions of text, images and the general appearance on translated pages. Google Translate may maintain unique privacy and use policies. These policies are not controlled by DoIT and are not associated with DoIT’s privacy and use policies. After selecting a translation option, users will be notified that they are leaving DoIT’s website. Users should consult the original English content on DoIT’s website if there are any questions about the translated content.

    DoIT uses Google Translate to provide language translations of its content. Google Translate is a free, automated service that relies on data and technology to provide its translations. The Google Translate feature is provided for informational purposes only. Translations cannot be guaranteed as exact or without the inclusion of incorrect or inappropriate language. Google Translate is a third-party service and site users will be leaving DoIT to utilize translated content. As such, DoIT does not guarantee and does not accept responsibility for, the accuracy, reliability, or performance of this service nor the limitations provided by this service, such as the inability to translate specific files like PDFs and graphics (e.g. .jpgs, .gifs, etc.).

    DoIT provides Google Translate as an online tool for its users, but DoIT does not directly endorse the website or imply that it is the only solution available to users. All site visitors may choose to use alternate tools for their translation needs. Any individuals or parties that use DoIT content in translated form, whether by Google Translate or by any other translation services, do so at their own risk. DoIT is not liable for any loss or damages arising out of, or issues related to, the use of or reliance on translated content. DoIT assumes no liability for any site visitor’s activities in connection with use of the Google Translate functionality or content.

    The Google Translate service is a means by which DoIT offers translations of content and is meant solely for the convenience of non-English speaking users of the website. The translated content is provided directly and dynamically by Google; DoIT has no direct control over the translated content as it appears using this tool. Therefore, in all contexts, the English content, as directly provided by DoIT is to be held authoritative.

    Severe Combined Immunodeficiency Disorder

    Severe Combined Immunodeficiency (SCID) includes a group of rare but serious, and potentially fatal, inherited immune disorders in which T lymphocytes fail to develop and B lymphocytes are either absent or compromised. Impairment of both B and T cells leads to the term “combined.” Untreated patients develop life-threatening, infections due to bacteria, viruses and fungi. The screening test for T cell receptor excision circles (TRECs), a byproduct of normal T cell development, identifies SCID as well as certain related conditions with low T cells. For example DiGeorge Syndrome with impaired thymus development may cause low T cells and low TRECs.  SCID is an autosomal recessive disorder, but can also be inherited as an X-linked disorder, affecting males whose mothers are a carrier for SCID. 
     
    Incidence:  1 out of every 50,000 to 100,000 births; however, an exact rate of occurrence cannot be determined until more states are screening newborns for the disease.
     
    Diagnosis: Diagnosis is made by obtaining a CBC with flow cytometry.  This testing should be coordinated with Immunology to improve accuracy of ordering and analysis of results.  Live vaccines should not be given to a patient with a potential SCID diagnosis until results of follow-up testing are known and are WNL.  Therefore, Rotovirus should not be administered in a patient who is currently undergoing a work-up for potential SCID.
     
    Treatment:  Bone marrow transplantation provides patients with a functioning immune system that is capable of protecting them from infections. Transplants from sibling matched donors continue to produce the best outcomes, when available. This is still a developing field and as new methods are tested, especially in the newborn population, increasingly better outcomes are being seen even in those without a matched sibling.
     
    False Positives:  False positive results are common in premature infants and infants with poor immune systems secondary to illness or other conditions.
     
    Resources: